Abstract
GENERAL COMMENTARY article Front. Physiol., 22 February 2012Sec. Vascular Physiology Volume 3 - 2012 | https://doi.org/10.3389/fphys.2012.00031
Highlights
In this review, Ming et al (2012) address the role of mammalian target of rapamycin (mTOR) complex 1 and its downstream effector S6K1 signaling pathway in aging and age- associated diseases
It has been hypothesized that some dietary regimes, like caloric restriction and methionine restriction, extends lifespan by decreasing mTOR activity (Kaeberlein et al, 2005)
One should keep in mind that the effects produced by caloric restriction and inhibition mTOR signaling are not straightforward correlated
Summary
In this review, Ming et al (2012) address the role of mTOR complex 1 and its downstream effector S6K1 (mTORC1– S6K1) signaling pathway in aging and age- associated diseases. The authors discuss the important new concept that augmented mTORC1–S6K1 signaling is critical in aging-related processes, and provides a link between aging and cardiovascular disturbances, such as vascular and cardiac remodeling seen, e.g., in diabetes, arterial hypertension, atherosclerosis, and heart failure.
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