MTHFR and ERVFRD-1 polymorphisms and preeclampsia risk in Iran population: A case-control study

Abstract

Background and aimsPreeclampsia (PE) is a complicated disease during pregnancy that could be a risk factor for the mother's health and fetus. The mechanisms of PE pathogenesis might associate with some candidate gene polymorphisms. This study is aimed to evaluate the relation between MTHFR (C677T) MTHFR (A1298C) and ERVFRD-1 (rs9393931) single nucleotide polymorphisms (SNPs) and PE in our patients. Material and methodsThe present study was a case-control study carried out between January 2019 and January 2021, in the Kamali hospital, Karaj, Iran. A total of 104 pregnant women who were diagnosed with Preeclampsia clinically as a case, and 100 healthy pregnant women as a control group were compared for the study. ResultsThere was not a 39 T allele of the ERVFRD-1 gene was observed in this studied population. There was a significant difference in frequency of 677CT genotype in PE pregnant women compared to controls (P = 0.002). Also, our result indicated that the frequency of the MTHFR 1298C allele was found to be significantly higher in the control group than in the case group (P = 0.021). ConclusionOur results suggested that C677T polymorphism in MTHFR might be related to an increased risk of Preeclampsia in pregnancy.