Abstract
BackgroundPrevious studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility.MethodsA systematic literature search on Embase, Pubmed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang electronic database identified 40 articles including 5725 cases and 8655 controls. Strength of association was evaluated by pooled odds ratio (OR), 95% confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0.ResultsThe meta-analysis results indicated a significant relationship between MTHFR gene A1298C polymorphisms and stoke risk under the C allelic genetic model (OR = 1.19, 95%CI = 1.07–1.32, p = 0.001), dominant genetic model (OR = 1.19, 95%CI = 1.06–1.33, p = 0.004) and recessive genetic model (OR = 1.43, 95%CI =1.15–1.77, p = 0.001). In subgroup analysis, we discovered obvious correlation in three genetic model of Asian, stroke type, adult by ethnicity, population, stroke type, source of control and case size. Additionally, in studies of control from hospital and case size equal 100, obvious correlation was also found in the three genetic model.ConclusionsOur meta-analysis results indicated that there was evidence to support the correlation between MTHFR A1298C polymorphism and stroke susceptibility, especially in adults and ischemic stroke.
Highlights
Stroke was a type of clinical syndrome caused by sudden neurological deficits after cerebral blood vessel rupture or occlusion
The meta-analysis results indicated a significant relationship between Methylenetrahydrofolate reductase (MTHFR) gene A1298C polymorphisms and stoke risk under the C allelic genetic model (OR = 1.19, 95%confidence interval (CI) = 1.07–1.32, p = 0.001), dominant genetic model (OR = 1.19, 95%CI = 1.06–1.33, p = 0.004) and recessive genetic model (OR = 1.43, 95%CI =1.15–1.77, p = 0.001)
We discovered obvious correlation in three genetic model of Asian, stroke type, adult by ethnicity, population, stroke type, source of control and case size
Summary
Stroke was a type of clinical syndrome caused by sudden neurological deficits after cerebral blood vessel rupture or occlusion. It had a very high rate of disability and was classified into ischemic stroke (IS) and hemorrhagic stroke (HS) [1, 2]. Methylenetrahydrofolate reductase (MTHFR) was a key enzyme that folic acid metabolizes in vivo. The activity of this enzyme can directly affect the plasma homocysteine content in the human body [5, 6]. Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. We conducted a meta-analysis to accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility
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