Abstract
MTH1 counteracts oncogenic oxidative stress.
Highlights
In effect, MTH1 loss compromises the overall robustness of the transformation circuit and enables the negative consequences of oncogenic oxidative stress on tumor formation
Whilst MTH1 may not be able to directly alter reactive oxygen species (ROS) levels, its loss can force reductions in oncogenic oxidants by selectively eradicating cells with high levels of RAS oncoprotein and/or ROS-generating downstream pathways that cannot cope with the consequences of MTH1 inhibition due to their elevated oxidant status
It is well known that approximately 50% of all tumors contain p53 mutations or loss that make them refractory to stresses that induce DNA damage
Summary
MTH1 loss compromises the overall robustness of the transformation circuit and enables the negative consequences of oncogenic oxidative stress on tumor formation. This characteristic places MTH1 in a unique class of non-oncogenic adaptation – the ability to mitigate the negative influences of ROS on tumor formation without directly altering the ROS levels required for oncogenic signaling.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
