MSR23 Improving the Interpretability of Ordinal Endpoints in NMAs

Abstract

Ordinal endpoints are common in NMAs for health technology assessment submissions. PASI is a continuous endpoint used in psoriasis trials that is typically reported as number of patients reaching 50/75/90/100% improvement. In NMAs, PASI is usually analyzed as an ordinal outcome leveraging the parallel lines or proportional odds assumption. While clinicians are familiar with % improvement thresholds, they may be more interested in summaries that not typically reported in trials: The full distribution of PASI % change, mean PASI % change, or median PASI % change. We provide proof-of-concept for a unified framework that allows estimation of clinically relevant estimates using any PASI NMA.