Abstract
Determine the in vitro antibacterial potential activity sidr honey produced in upper Egypt against five references bacterial strains (Gram positive and Gram negative strains) and its synergistic effect with some antimicrobial agents. Material & Methods: fifteen Sidr honey samples were collected from three Governorates in Upper Egypt. Honey samples were diluted and tested against Staphylococcus aureus, Streptococcus agalactiae, Escherichia coli, Klebsiella pneumoniae and Bacillus cereus by agar dilution method. Post determination of the minimum inhibitory concentration (MIC) values, six honey samples were examined for their synergistic action with the ineffective antimicrobial agents. Results: In vitro antimicrobial sensitivity test, all bacterial strains showed multidrug resistance action against the 13 tested antimicrobial agents with high multiple antibiotic resistance (MAR) index, it was ≥ 0.38. All Sidr bee honey samples showing antibacterial activity against the five tested references bacterial strains. All Sidr bee honey samples, showed better synergistic effect with all antimicrobial agents against.
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