Abstract
ABSTRACTChelsey C. Spriggs works in the field of DNA viral entry with a specific interest in virus-host interactions. In this mSphere of Influence article, she reflects on how two papers, “The HCMV assembly compartment is a dynamic Golgi-derived MTOC that controls nuclear rotation and virus spread” (D. J. Procter, A. Banerjee, M. Nukui, K. Kruse, et al., Dev Cell 45:83–100.e7, 2018, https://doi.org/10.1016/j.devcel.2018.03.010) and “Cytoplasmic control of intranuclear polarity by human cytomegalovirus” (D. J. Procter, C. Furey, A. G. Garza-Gongora, S. T. Kosak, D. Walsh, Nature 587:109–114, 2020, https://doi.org/10.1038/s41586-020-2714-x), impacted her research by reinforcing the scientific value in using viruses to understand cell biology.
Highlights
In the midst of this global pandemic, viruses are at the forefront of everyone’s mind— from scientific experts to the general public
How and why human cytomegalovirus (HCMV) induces nuclear rotation would become the basis of their paper
In order to further investigate this virus-induced phenomenon, Procter et al [2] developed convolutional neural network (CNN)-based automated cell classification and analysis pipelines to measure the spatial organization of thousands of individual cells
Summary
In the midst of this global pandemic, viruses are at the forefront of everyone’s mind— from scientific experts to the general public. The views expressed in this article do not necessarily reflect the views of the journal or of ASM. How and why HCMV induces nuclear rotation would become the basis of their paper.
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