Abstract
Felipe Santiago-Tirado studies the cell biology of cryptococcal infections. In this mSphere of Influence article, he reflects on how the papers "Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans" (https://doi.org/10.1016/j.cell.2008.07.046) and "Unraveling the Biology of a Fungal Meningitis Pathogen Using Chemical Genetics" (https://doi.org/10.1016/j.cell.2014.10.044) by the Noble and Madhani groups influenced his thinking by showcasing the various modern applications of yeast genetics in an organism where genetic manipulation was difficult.
Highlights
Despite referring to a type of cellular division that many organisms use, the term “budding yeast” is universally known to refer to the yeast Saccharomyces cerevisiae
In the follow-up paper, “Unraveling the Biology of a Fungal Meningitis Pathogen Using Chemical Genetics” [4], using a slightly larger deletion collection, the authors performed a systematic chemical-genetic interaction screen, another genomic assay first developed in S. cerevisiae [5]
Since the publication of that first partial deletion collection, several advances in the cryptococcal field have occurred that will certainly have a positive impact in the research
Summary
Despite referring to a type of cellular division that many organisms use, the term “budding yeast” is universally known to refer to the yeast Saccharomyces cerevisiae. The views expressed in this article do not necessarily reflect the views of the journal or of ASM. Commentary to the community an incredible useful resource.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
