Abstract
Objective The objective of the present work was to evaluate the DNA repair gene MSH2 expression in oral squamous cell carcinoma (OSCC). Study Design The carcinoma group was composed of 32 OSCC samples and the control group by 15 samples of tissue borders of benign lesions removed from the oral cavity of patients equivalent in age, sex, and smoking habits to the patients of OSCC group. Gene expression was assessed by quantitative reverse transcription polymerase chain reaction (RT-qPCR). In addition, clinical data, such as age, amount of cigarettes per day, time of tobacco consumption, smoking history (pack-years), degree of nicotine dependence, risk of alcohol use, and neoplasm staging were evaluated. The groups were compared using the Student t test and the correlation of the expression levels and clinical data were explored using the Pearson correlation coefficient, with P Results It was observed higher prevalence of males, with a mean age in years ± SD of 57.44 ± 13.32. The MSH2 gene was downregulated (1.13 fold decrease) in the OSCC group compared to the control with significant results (P = .0380). There was no significant correlation between MSH2 expression and the clinical variables studied. Conclusions MSH2 expression in OSCC was reduced.
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