MS12.02 Clinical Data Available

Abstract

The role of radiation is evolving in the era of immunotherapy. The abscopal effect of radiation on immune modulation has been discussed and researched greatly during recent days, and there is a significant amount of laboratory data suggesting its positive effect on tumor control. This presentation will focus on an objective review of clinical evidences for the clinical significant outcomes of radiation on immune function aiming to maximize the positive effect of Radiation Immunomodulation. Standing from the clinic, I will not only review the GOOD side of abscopal effect, i.e. the increased tumor control distant from a focused local radiation, and examine the BAD effect of radiation immunomodulation, i.e. radiation immunosuppressive effect which can worsen the tumor control outcome and overall survival. Starting from an overview of these two conflicted effects of all solid tumors in general, the presentation will specifically focus on the literature of radiation immunomodulation effects in patients with non-small cell lung cancer. Predictive and correlative biomarkers for both GOOD and BAD effects will also be reviewed through thorough literature search. The ultimate goal of this presentation is to motivate us, the oncologists to search, and research on finding a way to deliver a more effective radiation therapy and a more effective way of combined therapy with radiation and immunotherapy, to maximize the GOOD abscopal benefit while minimize the BAD effects of radiation on immunofunction. Radiation abscopal effect, radiation immunosuppression, biomarker