Abstract
Postural tachycardia syndrome (POTS) and inappropriate sinus tachycardia (IST) are diagnostic possibilities for a patient presenting in sinus tachycardia without any clear primary cause. While neither condition leads to increased mortality, either condition could negatively impact quality of life if not treated. A detailed history and physical exam including orthostatic vital signs are the foundation toward identifying other investigations that may be needed to rule out other causes of sinus tachycardia. There are no gold-standard treatments for POTS or IST. Experts agree that a multidisciplinary approach that considers the individual patients’ presentation is key for identifying potential therapeutic options for management.
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