MS Fragmentation of ALD-52 with GC-MS and LC-QTOF

Abstract

LSD (Lysergic acid diethylamide) is a widely used recreational drug usually take at around 100 mcg for extremely potent hallucinogenic effect. It first synthesized in 1938, synthetically made from lysergic acid. ALD-52, prodrug of LSD, was abused in various forms such as blotter paper, tablet or diluted as a liquid and the characteristic hallucinogenic effects of ALD-52 that stimulating pleasurable and mind-altering or an unpleasant, sometimes terrifying experience of LSD is via interaction with the serotonin receptors. The physical effects of ALD-52 distorted visual perception of shapes and colors, altered sounds, anxiety, depression, rapid increased heart rate, increased body temperature, high blood pressure, and diluted pupils. Experience flashback can last days or even months after taking the last dose and occurs suddenly, may also manifest relatively long-lasting psychoses such as schizophrenia or severe depression. Under the influence of ALD-52, the ability to make sensible judgements and see common dangers in impaired making the user susceptible to personal injury or death. Structure of ALD-52 is in which an acetyl group is added to the LSD. The molecule weight of ALD-52 is 365.210, major ions are m/z 365.3, 263.1, and 72.1, retention time is 20.37 min at GC-MSD. From the LC-QTOF results, specific MSMS fragmentations of 265.1326, 223.1217, 323.1746, and 366.2173 (M+H) of ALD-52 were confirmed.