Abstract

The purpose of this study is to investigate feasibility of estimating the specific absorption rate (SAR) in MRI in real time. To this goal, SAR maps are predicted from 3T- and 7T-simulated magnetic resonance (MR) images in 10 realistic human body models via a convolutional neural network. Two-dimensional (2-D) U-Net architectures with varying contraction layers and different convolutional filters were designed to estimate the SAR distribution in realistic body models. Sim4Life (ZMT, Switzerland) was used to create simulated anatomical images and SAR maps at 3T and 7T imaging frequencies for Duke, Ella, Charlie, and Pregnant Women (at 3, 7, and 9 month gestational stages) body models. Mean squared error (MSE) was used as the cost function and the structural similarity index (SSIM) was reported. A 2-D U-Net with 4 contracting (and 4 expanding) layers and 64 convolutional filters at the initial stage showed the best compromise to estimate SAR distributions. Adam optimizer outperformed stochastic gradient descent (SGD) for all cases with an average SSIM of 90.5∓3.6 % and an average MSE of 0.7∓0.6% for head images at 7T, and an SSIM of >85.1∓6.2 % and an MSE of 0.4∓0.4% for 3T body imaging. Algorithms estimated the SAR maps for 224×224 slices under 30 ms. The proposed methodology shows promise to predict real-time SAR in clinical imaging settings without using extra mapping techniques or patient-specific calibrations.

Highlights

  • Modern neuroscience relies on understanding the brain in health and disease

  • A key limitation to the high potential of ultra-high field (UHF) magnetic resonance imaging (MRI) in neuroscience research and clinical or diagnostic applications [2, 3] is the safety concern related to the nonuniform deposition of radiofrequency (RF) power in the body [4], quantified by the specific absorption rate (SAR), which can lead to dangerous tissue heating and damage [5]

  • learning rates (LR) chosen over a range from 10-3 to 10-5 resulted in similar structural similarity index (SSIM)

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Summary

Introduction

Modern neuroscience relies on understanding the brain in health and disease. the availability of technology that can significantly increase the spatial resolution and sensitivity achievable with magnetic resonance (MR) neuroimaging at the current used field strength of 3T and emerging ultra-high field (UHF) strengths of 7T and higher, consistent with safety, would offer the potential to advance our understanding of brain structure and function by enabling investigations with greater specificity and granularity [1].A key limitation to the high potential of UHF magnetic resonance imaging (MRI) in neuroscience research and clinical or diagnostic applications [2, 3] is the safety concern related to the nonuniform deposition of radiofrequency (RF) power in the body [4], quantified by the specific absorption rate (SAR), which can lead to dangerous tissue heating and damage [5]. Does the average SAR possess a quadratic dependence on the static magnetic field strength (B0) [6], increasing 4-fold from 3T to 7T, but due to the higher Larmor frequency and shortened in-tissue wavelength, it exhibits a spatial variation that can lead to “local SAR” patterns or “hotspots” of focused high RF power deposition and localized tissue heating [7-13]. This results in significant SAR nonuniformity at anatomical dimensions similar to the brain at 7T (wavelength ~11 cm in tissue) as well as the body at 3T (wavelength ~26 cm in tissue) [14].

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