MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes

H Wittkowski,J B Kuemmerle-Deschner,D Foell,K Gramlich,S M Benseler,P Lohse,T Jung,R Goldbach-Mansky,J Roth,J Austermann,D Holzinger

doi:10.1136/ard.2011.152496

MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes

H Wittkowski, J B Kuemmerle-Deschner + Show 9 more

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https://doi.org/10.1136/ard.2011.152496

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Journal: Annals of the Rheumatic Diseases	Publication Date: Sep 8, 2011
Citations: 64

Affiliation: University Hospital Münster, University of Tübingen, Ludwig-Maximilians-Universität München, Novartis (Switzerland), National Institute of Arthritis and Musculoskeletal and Skin Diseases

#Chronic Infantile Neurological, Cutaneous And Articular #Cryopyrin-associated Periodic Syndromes + Show 8 more

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Abstract

ObjectivesTo assess the sensitivity of the phagocyte-specific molecules myeloid-related protein (MRP) 8 and MRP14 (calprotectin) for monitoring disease activity during anti-interleukin (IL)-1 therapies in patients with cryopyrin-associated periodic syndromes (CAPS),...

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