Abstract
This chapter discusses that the histone mRNAs \and the nonhistone mRNAs either containing or lacking poly (A), comprise distinctly different nucleotide sequences. Therefore, they represent three separate classes of genes. The synthesis of mRNA corresponding to each of these gene classes changes during early development of the sea urchin embryo in a different and characteristic way. Therefore, these syntheses appear to be under separate controls, seemingly related to developmental changes in cellular requirements. It reviews that translation of mRNA (A n ) appears to be controlled differently from that of mRNA (no A n ), especially as a function of embryonic development. Messenger RNAs of both classes are underloaded with ribosomes in the early embryo. However, with development to the late gastrula stages, loading of the mRNA (no A n ) approaches theoretical levels, whereas that of the mRNA (no A n ) increases only slightly. A developmental change in initiation activity may be operative, with one mRNA class being affected more than the other. General gene classes are distinguished by the presence or absence of poly (A) in their product mRNAs. These distinct gene classes are separately regulated in the production and translation of their mRNAs.
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