Abstract
The growth of expertise in molecular techniques, their application to clinical evaluations, and the establishment of databases with molecular genetic information has led to greater insights into the roles of molecular processes related to gene expression in neurodevelopment and functioning. The goal of this review is to examine new insights into messenger RNA transcription, translation, and cellular protein synthesis and the relevance of genetically determined alterations in these processes in neurodevelopmental, cognitive, and behavioral disorders.
Highlights
Reviewed by: Ye Fu, Harvard University, United States Lysangela Ronalte Alves, Carlos Chagas Institute (ICC), Brazil
The goal of this review is to examine new insights into messenger RNA transcription, translation, and cellular protein synthesis and the relevance of genetically determined alterations in these processes in neurodevelopmental, cognitive, and behavioral disorders
The repeat expansion involved TTTCA and TTTTA repeats. They noted that repeat expansions of TTTTA and TTCA were noted in two different genes TNRC6A and RAPGEF2 in cases of familial myoclonic epilepsy
Summary
Reviewed by: Ye Fu, Harvard University, United States Lysangela Ronalte Alves, Carlos Chagas Institute (ICC), Brazil. Specialty section: This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences. The growth of expertise in molecular techniques, their application to clinical evaluations, and the establishment of databases with molecular genetic information has led to greater insights into the roles of molecular processes related to gene expression in neurodevelopment and functioning. The goal of this review is to examine new insights into messenger RNA transcription, translation, and cellular protein synthesis and the relevance of genetically determined alterations in these processes in neurodevelopmental, cognitive, and behavioral disorders
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