Abstract
Objective:To observe the mRNA expression of BCSG1(breast carcinoma specific gene,BCSG1),BTF(Bcl-2-associated transcription factor,BTF),Bcl-2(B cell lymphoma/leukemia-2,Bcl-2) and two subtypes of estrogen receptors in osteosarcoma and their implication.Methods: The expression of BCSG1,ERα,BTF,ERβ,and Bcl-2 mRNA were examined in 16 poorly differentiated osteosarcoma samples and a cell line hFOB 1.19 by quantitative RT-PCR.The relationship between their expression was analyzed.Results: The mRNA expression of BCSG1,Bcl-2 and two subtypes of estrogen receptors in the osteosarcoma tissues was significantly higher than that in the osteoblast cell line of hFOB 1.19;the expression of BTF was not significantly different.ERα/ERβ in the osteosarcoma tissues was significantly higher than that in the hFOB 1.19 cells(P0.01).BCSG1,ERα,ERβ,Bcl-2 and BTF expression was not associated with the tumor size or patients gender.Correlation analysis showed there was a linear relationship between expression of BCSG1 and ERα,ERβ and Bcl-2,and ERα/ERβ ratio and Bcl-2.Conclusion: BCSG1 may enhance the activation of estrogen receptor-α gene transcription,and ERβ may influence the expression of Bcl-2 in osteosarcoma.
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