Abstract
This is an attempt to explain mRNA-dependent non-stationary semantic values of codons (triplets) and nucleotides (letters) in codon composition during protein biosynthesis. This explanation is realized by comparing the different protein codes of various biosystem taxa, and, comparing mitochondrial code with the standard code. An initial mRNA transcriptional virtuality (Virtual-Reality) is transformed into material reality at the level of translation of virtual triplets into real (material) amino acids or into a real stop command of protein biosynthesis. The transformation of virtuality into reality occurs de facto when the linguistic sign1 functions of the codon syhoms are realized in the 3’ nucleotide (wobbling nucleotide according to F. Crick) in the process of protein biosynthesis. This corresponds to the theoretical works of the authors of this article. Despite the illusory appearance of semantic arbitrariness during the operation of ribosomes in the mode of codon semantic non-stationarity, this phenomenon probably provides biosystems with an unusually high level of adaptability to changes in the external environment as well as to internal (mental) dynamics of neuron’s genome in the cerebral cortex. The genome’s non-stationarity properties at the nucleotide, codon, gene and mental levels have fractal structure and corresponding dimensions. The highest form of such fractality (with maximum dimension) is probably realized in the genomic continuum of neurons in the human cerebral cortex through this semantic Virtual-to-Real (VR) codon transcoding with the biosynthesis of short-living semantic proteins, as the equivalents of material thinking-consciousness. In fact, this is the language of the brain’s genome, that is, our own language. In this case, the same thing happens in natural, primarily mental (non-verbal) languages. Their materialization is recorded in vocables (sounding words) and in writing. Such writing is the amino acid sequence in the semantic proteins of the human cerebral cortex. Rapidly decaying, such proteins can leave a long-lasting “so-called” Schrödinger wave holographic memory in the cerebral cortex. The presented below study is purely theoretical and based on a logical approach. The topic of the study is very complex and is subject to further development.
Highlights
Let’s consider a structurally modified standard (Table 1) of the Genetic Protein Code
Demonstrativeness of these real material two-way inter-code information exchanges once again suggests that the path of syhom →synonymous transcoding can occur virtually, i.e. at the level of their semantics for all encoding syhom-synonymous doublets according to the following scheme: one word is written but another word is understood. This real phenomenon can be signifying a warning informing message to us about the importance of understanding the protein code as a dynamic system of meanings, originally set by the texts of genes at the stage of their transcription into mRNA and, secondly, at the stage of their translation into semantic proteins. We have studied such a path as a property of “delegation” of other meanings from mRNA to “wobbling”
At the same time, it was referring to the mental, conscious nature of protein genetic coding, since the choice of two different amino acids simultaneously encoded by the syhom-codon can only be made after reading and understanding the meaningful context of the mRNA text using the ribosome as a nanobiocomputer
Summary
Let’s consider a structurally modified standard (Table 1) of the Genetic Protein Code. The third level of the fractal semantic dimension of letters in triplets is represented by the triplets of nucleotides as integral semantic units of 32 codons-synonyms, unambiguously encoding amino acids, already as letters of the semantic continuum of proteins as texts They can be the objects of VR-transcoding. The definition of the genetic code of the highest fractal dimension can be refined as a continuum of probabilistic meanings of synthesized proteins during the work of the cerebral cortex [4] It is the dynamics of thinking and consciousness, that requires the use of an infinitely diverse combinatorics of transcoding of the Code’s triplets, resulting in the protein complement as a material reflection of Consciousness-Thinking. This vector is beginning to organize our work differently
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