Abstract
The cell can precisely regulate expression of any given gene by controlling the rates of transcription and mRNA decay. Although mRNA decay rates can differ by a factor of >100, relatively little is known about the global regulation of this process. Now, Wang et al. [ 1. Wang Y. et al. Precision and functional specificity in mRNA decay. Proc. Natl. Acad. Sci. U. S. A. 2002; 99: 5860-5865 Crossref Scopus (547) Google Scholar ] have started to redress this imbalance by undertaking a global profiling of mRNA turnover in yeast. They found that mRNA decay rates did not generally correlate with any obvious molecular characteristic but instead seemed to relate to the physiological function of the corresponding gene product.
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