Abstract
Previous studies have shown a reduction of dopaminergic D<sub>2</sub> receptors (D<sub>2</sub>R) in the striatum after hypoxia-ischemia in newborn rats. We show here an early and transient reduction of mRNA D<sub>2</sub>R in nonatrophic brains following hypoxia-ischemia. The left carotid artery of P7 rats was ligated followed by hypoxia for 2 h. The rats were sacrificed after 24 h, 48 h and 14 days. D<sub>2</sub>R mRNA was studied by in situ hybridization, the cell number by conventional histology, and neuronal and astrocyte differentiation by immunohistochemistry. A 20% reduction of striatal mRNA D<sub>2</sub>R occurred 24 h after hypoxia-ischemia, whereas no reduction was observed after 48 h and 14 days. There were no differences in total cell number and in the expression of neuronal (MAP-1, MAP-2) and astrocyte (GFAP) markers between both brain hemispheres nor between control and hypoxia-ischemia animals. The early decrease in mRNA D<sub>2</sub>R could explain the delayed reduced D<sub>2</sub>R after neonatal hypoxia-ischemia.
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