MRI-Based Heart and Torso Personalization for Computer Modeling and Simulation of Cardiac Electrophysiology

Abstract

In the last decade, electrophysiological models for in-silico simulations of cardiac electrophysiology have gained much attention in the research field. However, to translate them to clinical uses, the models need personalization based on recordings from the patient. In this work, we explore methodologies for the patient-specific personalization of torso and heart geometric models based on standard clinical cardiac magnetic resonance acquisitions to enable simulations. The inclusion of the torso and its internal structures allows simulations of the human ventricular electrophysiological activity from the ionic level to the body surface potentials and to the electrocardiogram.