Abstract
To demonstrate an MRI pulse sequence-Sub-millisecond Periodic Event Encoded Dynamic Imaging with a reduced field of view (or rFOV-SPEEDI)-for decreasing the scan times while achieving sub-millisecond temporal resolution. rFOV-SPEEDI was based on a variation of SPEEDI, known as get-SPEEDI, which used each echo in an echo-train to sample a distinct k-space raster by synchronizing with a cyclic event. This can produce a set of time-resolved images of the cyclic event with a temporal resolution determined by the echo spacing (typically < 1 ms). rFOV-SPEEDI incorporated a 2D radiofrequency (RF) pulse into get-SPEEDI to limit the field of view (FOV), leading to reduction in phase-encoding steps and subsequently decreased scan times without compromising the spatial resolution. Two experiments were performed at 3T to illustrate rFOV-SPEEDI's capability of capturing fast-changing electric currents in a phantom and the rapid opening and closing of aortic valve in human subjects over reduced FOVs. The results were compared with those from full FOV get-SPEEDI. In the first experiment, the rapidly varying currents (50-200 Hz) were successfully captured with a temporal resolution of 0.8 ms, and agreed well with the applied currents. In the second experiment, the rapid opening and closing processes of aortic valve were clearly visualized with a temporal resolution of 0.6 ms over a reduced FOV (12 × 12 cm2 ). In both experiments, the acquisition times of rFOV-SPEEDI were decreased by 33%-50% relative to full FOV get-SPEEDI acquisitions and the spatial resolution was maintained. Reducing the FOV is a viable approach to shortening the scan times in SPEEDI, which is expected to help stimulate SPEEDI applications for studying ultrafast, cyclic physiological and biophysical processes over a focal region.
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