Abstract
Investigators from Washington University School of Medicine and University of Florida College of Medicine, report that susceptibility-weight imaging (SWI) may be useful in differentiating initial presentation of pediatric multiple sclerosis (MS) from acute disseminated encephalomyelitis (ADEM).
Highlights
The 2010 McDonald Criteria for diagnosing multiple sclerosis are not as sensitive or specific in pediatric patients when including those with Acute disseminated encephalomyelitis (ADEM) [3]
In adults with multiple sclerosis (MS), susceptibility-weighted imaging (SWI) may recognize the presence of iron in MS lesions, visualize lesions missed by conventional imaging techniques, and identify particular lesion characteristics [4]
The precise prevalence is unknown, an estimated 2 to 5% of all persons with multiple sclerosis (MS) have onset of symptoms before 16 years of age [2]
Summary
The precise prevalence is unknown, an estimated 2 to 5% of all persons with multiple sclerosis (MS) have onset of symptoms before 16 years of age [2]. The major challenge to diagnosing MS in the pediatric population is to distinguish transient demyelinating events from life-long MS, and to differentiate MS from other inflammatory or infectious conditions. Acute disseminated encephalomyelitis (ADEM) is an inflammatory disorder of the CNS presenting with multifocal, mainly white matter, abnormalities of the brain and spinal cord.
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