MRI of the ulnar nerve pre- and post-transposition: imaging features and rater agreement

Abstract

Determine the rater agreement of MRI features of the ulnar nerve pre- and post-transposition and association with recurrent symptoms. This IRB-approved retrospective cohort analysis examined 23 subjects who underwent elbow MRI pre- and post-ulnar nerve transposition from 1999 to 2018, 10 of whom developed recurrent symptoms. Pre- and post-transposition MRIs were evaluated by two blinded radiologists for ulnar nerve cross-sectional area, signal intensity, fascicular architecture, caliber change, and perineural scar. Inter-rater agreement was estimated using intraclass correlation coefficients (ICCs) for continuous variables and Gwet's agreement coefficient (AC) for categorical variables. Binary logistic regression modeling probed associations between imaging markers and symptom recurrence. The ulnar nerve, post-operatively, demonstrated statistically significant increases in size (p < 0.001), signal intensity (p = 0.021), and abrupt caliber change (p = 0.024). None of the imaging features, except for higher signal intensity of the nerve pre-transposition as demonstrated by one rater, were predictive of symptom recurrence. Inter-rater agreement for cross-sectional area measurements of the ulnar nerve at the cubital tunnel was excellent (ICCs of 0.91 and 0.83). Substantial-to-excellent inter-rater agreement was observed pre-operatively for nerve signal intensity, caliber change, and fascicular architecture. Post-operatively, agreement on nerve signal intensity and perineural scar was excellent (ACs of 0.90 and 0.88), but only slight for caliber change (0.15). Inter-rater agreement for qualitative and quantitative assessment of the ulnar nerve was generally robust. Post-transposition, the ulnar nerve was generally larger and more T2-hyperintense, but MRI features were not predictive of recurrent ulnar neuropathy, except for perhaps the signal intensity of the nerve pre-transposition.