Abstract
To analyze potential of different MRI methods in the quantitative assessment of brain lesions after ischemic stroke, 19 patients (mean age 38.9±6.2 years) with hemiparesis of various severity resulted from supratentorial ischemic stroke (6–12 months prior the examination) were studied. A relationship was established between such parameters as fractional anisotropy (FA), apparent diffusion coefficient (ADC), size of the brain lesion, and severity of motor deficit. The FA and ADC values obtained in the corticospinal tract (CST) projection allow them to be considered as indicators of the degree of the CST post-ischemic damage predicting motor deficit. FA was found to be the most reproducible indicator of the CST structural integrity. FA threshold values (index, %) for unfavorable outcome of the motor function restoration were determined as follows: 50% for posterior limb of internal capsule, 42% for cerebral peduncle, and 65% for pons varolii. High sensitivity and specificity of the obtained parameters provides ground for their use in identifying patients with poor prognosis for the motor function restoration.
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