Abstract

The purpose of this study was to review MRI findings in Minamata disease (MD), and to correlate these with visual field abnormalities. MRI at 1.5T and visual field tests were performed in 20 patients with a mild type of MD, 8 patients with typical MD, and 10 control subjects. The atrophic portions of the calcarine areas were measured in the sagittal planes. In patients with constriction of the visual fields, the anterior portion of the calcarine fissure was significantly dilated, reflecting atrophy of the visual cortex. There was significant correlation between the degree of the temporal visual fields and the width of the calcarine sulci (r = 0.753, P< 0.0001). MRI has proved to be useful in studying abnormalities of the calcarine area due to methylmercury poisoning.

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