MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1: report of two cases.

Abstract

Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors arerefractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will havea positive impact on the outcome of these patients. We report on two illustrated cases of pediatric NF1-associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy(LITT). Both tumors responded favorably to LITT. LITT should be considered as a treatmentoption for chemoresistant deep-seated NF1-associated low-grade gliomas.