Abstract
Background Current treatment guidelines recommend surgical bypass for peripheral chronic total occlusions (CTOs)[1]. Percutaneous transluminal angioplasty (PTA), however, offers a less invasive approach with improved perioperative morbidity, shorter length of hospital stay, and lower cost[2]. Not all lesions are amenable to this technique and there is a significant primary failure rate[2]. Predicting lesion crossability is difficult because current imaging techniques offer limited information with which to characterize CTOs. The ability to distinguish between hard and soft biological substances that compose a CTO can aid procedural planning and facilitate intervention. This pilot study demonstrates the ability of high resolution MRI to characterize peripheral CTO components with microCT and histologic validation.
Highlights
Current treatment guidelines recommend surgical bypass for peripheral chronic total occlusions (CTOs)[1]
MRI was performed on 10 excised human peripheral arterial CTO segments from 3 patients
A difference image was produced by subtracting the complex signal values of the 1ms-image from those of the 20μs-image
Summary
Current treatment guidelines recommend surgical bypass for peripheral chronic total occlusions (CTOs)[1]. Methods MRI was performed on 10 excised human peripheral arterial CTO segments from 3 patients. Imaging system) at high resolution (75x75x75μm voxels) to produce three-dimensional T2- and T2*weighted images.
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