Abstract
The development of simultaneous therapy and imaging systems (Theranostics) for micro RNA (miRNA) is demanded the clinical application of RNA interference (RNAi) in cancer treatment and immune therapy. In this paper, we report a pH-sensitive, magnetic nanoparticle-based miRNA delivery system that can enable the safe and effective delivery, imaging by high-resolution Magnetic Resonance Imaging (MRI) and therapeutic ability through regulating tumor metastasis and immune evasion via miRNA34a. Cationic poly-L-lysine-graft (PL) with a reactive silane, moiety was stably immobilized onto the surface of the assembled manganese ferrite nanoparticles (MFs) through an emulsion process, ensuring high water solubility, enhanced MR contrast effect, and endosomedisrupting functionality. The MRI-based theranostic nano vectors (MNVs) were then complexed with miRNA34a via electrostatic interaction to verify the regulation for cancer metastasis by CD44 and immune avoidance by regulating PD-L1. These results showed a novel the platform for synergetic cancer therapy based on miRNA.
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