Abstract
pulvinar signal for the diagnosis of vCJD. The DWI pattern of vCJD was correlated with the known pathological data. We observed slightly increased ADC values in the pulvinar and low ADC values in the striatum. Low ADC values in CJD are presumably a result of spongiform cellular changes, which, on pathological examination of brains affected by vCJD are seen to predominate in the striatum. Conversely, neuropathological evidence of gliosis and neuronal loss with moderate spongiform changes in the pulvinar are consistent with increased ADC values in the pulvinar. The relevance of MRI findings in patients with vCJD is highlighted by the results of DWI, which closely parallel the pattern of abnormal tissue seen histologically. The widespread use of MRI in patients with persistent early psychiatric features despite appropriate psychiatric treatment could provide a valuable source of epidemiological data on the emerging epidemic of vCJD, and therefore has public-health implications.
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