Abstract
Hyperpolarized 129Xe MRI and magnetic resonance spectroscopy (MRS) of mouse heads have been measured under a high magnetic field of 9.4 T. The 129Xe MRS at 9.4 T has given a few split signals near 200 ppm and the 129Xe MRI measured with the main peak near 200 ppm has given the brain image that matches well with the contour of the brain in the 1H reference image. Also, a time course study after 129Xe gas inhalation has given a dynamic profile of distribution of 129Xe in the mouse brain. From these results, the dissolved-phase peaks were assigned as: 197 ppm (brain tissue), 192 ppm (plasma) and 208 ppm (RBC). Such an observation at a high magnetic field and assignment of the signal will be useful for the development of brain functional analysis.
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