Abstract
Neuroanatomical correlates of developmental dyslexia (DD), defined by isolated reading deficits, and specific language impairment (SLI), defined by poor receptive and expressive language skills, were examined using MR imaging in a heterogeneous sample of 14 boys and 8 girls (11-16 yers of age) with learning disabilities, in a study at University of Florida; Georgetown University, Washington, DC; and other centers.
Highlights
The impaired development of the secondary orbital sulci is consistent with the premature birth before 32 weeks, and before these sulci have formed
The sulcal abnormality appears to correlate with gray-matter volume reduction
The authors conclude that the orbitofrontal sulcal abnormality is a sequel of premature birth or neonatal complications
Summary
Neuroanatomical correlates of developmental dyslexia (DD), defined by isolated reading deficits, and specific language impairment (SLI), defined by poor receptive and expressive language skills, were examined using MR imaging in a heterogeneous sample of 14 boys and 8 girls (11-16 yers of age) with learning disabilities, in a study at University of Florida; Georgetown University, Washington, DC; and other centers. The impaired development of the secondary orbital sulci is consistent with the premature birth before 32 weeks, and before these sulci have formed. The primary sulci appear at 16 weeks' gestation and are well formed at 25 weeks.
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