Abstract

MRgFUS represents a promising alternative for patients with. chronic neuropathic that have failed medical management and other treatment options. Early single center experience with chronic neuropathic pain and Trigeminal Neuralgia has demonstrated favorable long-term outcomes. Excellent safety profile with low risk of motor and sensory complications and so far anecdotal permanent neurological deficits make FUS a powerful tool to treat patients that are otherwise hopeless. Neuromodulation may be the most influential factor driving outcomes and studies devised to detect neuroplasticity will be critical to guide such therapies. Future studies should focus on investigating other potential targets, such as the cingulate gyrus or the mesencephalon, as well as integrating control populations in trials.

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