Abstract
In Reply.— The conclusions referred to by Dr Rosborough et al are that, after 10.5 years of follow-up, mortality rates were lower for MRFIT men who received special intervention than for men who received their usual care by 10.6% for coronary heart disease and 7.7% for all causes, and that these reductions were primarily due to a 24% lower death rate from acute myocardial infarction for men in the special intervention group than for those receiving usual care. Also, for the large subgroup, those free of abnormalities at baseline in electrocardiograms taken with the patient resting, men in the special intervention group had mortality rates 21% lower for coronary heart disease and 16% lower for all causes. The issues raised about P values are important, but such numbers should not be the sole basis for interpretation of the results and support for the study hypotheses. Dr Rosborough et al
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