MR -specific characteristics of left ventricular noncompaction and dilated cardiomyopathy

Abstract

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Thematic Excellence Programme (Tématerületi Kiválósági Program, 2020-4.1.1.-TKP2020) of the Ministry for Innovation and Technology in Hungary within the framework of the Therapeutic Development and Bioimaging Programs of Semmelweis University Development of Scientific Workshops of Medical, Health Sciences and Pharmaceutical Edication (Project identification number: EFOP- 3.6.3-VEKOP-16- 2017-00009) Project no. NVKP_16-1–2016-0017 (’National Heart Program’) has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the NVKP_16 funding scheme. The research was supported by the Ministry of Innovation and Technology NRDI Office within the framework of the Artificial Intelligence National Laboratory Program. The differentiation of dilated cardiomyopathy (DCM) and left ventricular noncompaction (LVNC) is a recurring issue during cardiac imaging processes; thus, we aimed to compare the left ventricular (LV) cardiac MRI (CMR) characteristics of DCM and LVNC patients. Thirty-one nonischemic DCM patients, 42 LVNC patients with reduced EF and 42 healthy controls were included in this retrospective study. The LV volumetric, functional and myocardial mass parameters were measured with a threshold-based technique, while global and segmental strain values and rotational patterns were analyzed with feature-tracking strain analysis. Of the LV volumetric and myocardial mass parameters, only the trabeculated and papillary muscle mass (TPMi) values differed significantly between the patient groups and were higher in the LVNC group compared to DCM (DCM vs LVNC: 43.2 ± 8.9 vs 51.6 ± 13.6 g/m2, p < 0.002). The global longitudinal and circumferential strains were similar between the patient groups and significantly worse than those of the controls. In comparing the segmental strain values between the patient groups, only the circumferential apical strain was significantly lower in the LVNC group (DCM vs LVNC: -30.5 ± 13.5 vs -24.5 ± 12.0%, p < 0.05). There was no difference in the rotational pattern between the patient groups, and both the healthy and patient populations showed heterogeneous rotational patterns. Despite the similarities of DCM and LVNC in volumetric, global strain parameters, and rotational patterns, we found some morphological and functional differences between the patient groups. These minor alterations might be due to the morphological characteristics of LVNC with a trabeculated apical region.