Abstract
The results of MRI of the brain in adults with non-Wilsonian chronic hepatic failure are reported. T1-weighted images demonstrated increased signal in the basal ganglia. These abnormalities are strikingly similar to those seen following manganese (Mn) intoxication. The causes of this high signal have been thought to include paramagnetic substances, especially Mn, which accumulates within the basal ganglia in liver cirrhosis, because of its increased concentration in whole blood. Mn neurotoxicity may contribute to the development of chronic hepatic encephalopathy so that therapies which prevent or reduce Mn overload may have clinical benefit.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
