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Abstract
Results from randomized dose escalation studies for locally advanced non-small cell lung cancer (NSCLC) have been disappointing. Secondary analysis of RTOG 0617 indicates that dose escalation may have failed because of increased cardiopulmonary toxicity. MR-guided treatment delivery allows for real time visualization of targets and the use of small margins for treatment. We hypothesized that using an MR-guided (MRIdian system) approach to deliver a conventionally fractionated plan with an SBRT boost would significantly decrease target volume size and allow significantly lower dose to organs at risk (OAR).
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