MR dynamic enhancement, DWI/ADC value and prostatic cancer Gleason grading

Abstract

Objective To analyze the relationship between multi-parameter imaging of MR dynamic enhancement, DWI/ADC and Gleason grade of prostate cancer. Methods Retrospective analysis of clinical data of 40 patients with prostate disease in our hospital from January 2015 to September 2016 was performed. Among the 40 cases, 20 cases of prostate cancer, 20 cases of non-cancer, all patients were taken to the prostate MR routine, dynamic (T2WI) , T2WI+ DCE-MR, T2WI+ DWI, T2WI+ DCE-MR+ DWI, and the diagnostic accuracy of MR imaging with DWI was evaluated. Results Sensitivity, accuracy and specificity of T2WI+ DCE+ DWI in the diagnosis of prostate cancer were the highest, and diagnostic sensitivity, accuracy and specificity of T2WI for prostate cancer were the lowest. There was statistically significant difference in sensitivity and accuracy between two groups (P<0.05). There was statistically significant difference in diagnostic sensitivity, accuracy and specificity between T2WI T2WI+ DWI and T2WI+ DCE-MR+ DWI by four kinds of inspection programs(P<0.05). There was statistically significant difference in DWI/ADC values in patients with prostate cancer of different Gleason levels and scores by the single factor analysis of variance(P<0.05). DWI/ADC value was negatively correlated with the Gleason grading of prostate cancer by Spearman correlation test(P<0.05), and at the same time, DWI/ADC value was negatively correlated with prostate cancer Gleason score by the single factor analysis of variance(r=-0.412, P<0.05). Conclusions MR imaging, DWI/ADC and other parameters can significantly improve the diagnostic sensitivity and accuracy of prostate cancer, and can be used to assess the degree of malignancy and prognosis of prostate cancer by detecting DWI / ADC. Key words: Pr ostatic Neoplasms; Magnetic Resonance Imaging