Abstract
Although there is a clear need for improving men's health, treatment with suitable natural substances has not yet been well established. Previously, it was reported that MR-10, a novel complex of Korean dandelion and rooibos found by screening many natural products, improved sperm generation and activity. Here, the ability of MR-10 to increase testosterone levels and enhance men's health was tested. Treatment with MR-10 (400 mg/day) for a month significantly increased levels of free testosterone, total testosterone, and the testosterone precursor dehydroepiandrosterone by 22%, 14%, and 32%, respectively, in clinical studies. Also, men's health in terms of mental, physical, and sexual aspects, as determined by using the clinical questionnaires Androgen Deficiency of Aging Men and Aging Males' Symptoms, was improved. Furthermore, the safety of MR-10 was determined by testing levels of prostate-specific antigen, glutamic oxaloacetic transaminase, and glutamic pyruvate transaminase; and the lack of changes due to MR-10 treatment supports the safety of MR-10. In conclusion, this study suggests that MR-10 is a safe and effective natural product improving men's sexual health.
Highlights
T HE HEALTH OF AGING MEN is closely related to the male hormone testosterone
The levels of TT, Free testosterone (FT), and DHEA were *14.4% (P = .010), 22.4% (P = .000), and 32% (P = .003) higher than basal levels, respectively, after ingestion of MR-10 for 4 weeks, whereas there were no differences in their levels in the placebo control group (Fig. 1A–C)
We evaluated whether MR-10 improved the andropause symptoms using clinical questionnaires Androgen Deficiency of Aging Men (ADAM) and Aging Males’ Symptoms (AMS)
Summary
T HE HEALTH OF AGING MEN is closely related to the male hormone testosterone. Testosterone deceases by *1% per year after the age of 30. The process of aging in men involves various changes in the body, mainly caused by a gradual decline in the levels of testosterone and its metabolic precursor, dehydroepiandrosterone (DHEA).[1] Despite the fact that DHEA is a precursor of sex hormones, there have been reports of conflicting studies on the correlation with testosterone concentrations. A decline in the FT level is a hallmark of andropause, an androgen deficiency syndrome[4,5,6] marked by decreased energy and physical activity, depression, decreased libido, erectile dysfunction, decreased muscle mass and strength, increased fat mass, frailty, and osteopenia.[7,8,9] Changes in sex hormone-
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