Abstract
BackgroundTuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB’s high infection and mortality rates, there is an urgent need to develop a fast, portable, and sensitive diagnostic technology for its detection.MethodsWe included research from PubMed, Cochrane Library, Web of Science, and Embase and extracted the data. MetaDisc and STATA were used to build forest plots, Deek’s funnel plot, Fagan plot, and bivariate boxplot for analysis.ResultsForty-six articles were analyzed, the results of which are as follows: sensitivity and specificity were 0.92 (0.91–0.93) and 0.95 (0.94–0.95) respectively. The NLR and PLR were 0.04 (95% CI 0.03–0.07) and 25.32 (95% CI 12.38–51.78) respectively. DOR was 639.60 (243.04–1683.18). The area under the SROC curve (AUC) was 0.99.ConclusionsMPT64 exhibits good diagnostic efficiency for MTB. There is no obvious heterogeneity between the three commercial kits.
Highlights
There is no obvious heterogeneity between the three commercial kits
Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB)
The Global Tuberculosis Report 2019 stated that in 2018, about 1.5 million people worldwide died of TB and nearly 10 million people died from MTB, of which only 6.4 million were diagnosed and officially reported
Summary
Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with MTB (LTBI) during the incubation period without any obvious symptoms [1]. The conventional technique for detecting MTB in an analytical sample (such as pus, sputum, or tissue biopsy) takes two to 6 weeks. For the rapid detection of MTB, many techniques have been developed, such as ELISA (enzyme-linked immunosorbent assay), real-time polymerase chain reaction (PCR), latex agglutination, Gen-Probe amplified M. An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB’s high infection and mortality rates, there is an urgent need to develop a fast, portable, and sensitive diagnostic technology for its detection
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