MPS 10-09 Degree of nocturnal blood pressure in pregnancy might be associated with enlargement of the left atrial volume

Abstract

Objective: Few studies have been accessed the association between diastolic function and dipping pattern in pregnancy. The aims of this study access the association between diastolic function and dipping pattern in pregnancy. Design and Method: The study was a retrospective analysis of the findings in 125 pregnant patients performed 24hr ambulatory blood pressure monitoring (ABPM) and echocardiography. All pregnant patients were referred for initial evaluation of high BP and dyspnea in late third trimester of pregnancy. We enrolled the pregnant patients with normal ABPM result (mean ABPM < 130/80 mmHg) between 20 and 34 years. We exclude the pregnant patients with antihypertensive medication or past history of hypertension. Degree of night BP reduction was calculated as (1- (Mean SBP in night time/Mean SBP in day time) x 100. Results: The patients were mean gestational age of 29 ± 3 months. Mean ABPM was 123.4/84.5 mmHg (mean day ABPM: 126.3/84.1 mmHg, mean night ABPM: 117.5/75.6 mmHg). Mean degree of night BP reduction was 8.8 ± 6.1. In echocardiography, mean left ventricular ejection fraction and E/E′ was 61.8% and 8.9, respectively. In addition, mean LAV index and LVM index were 29.3 mL/m2 and 114.9 g/ m2. And mean E/E′ and deceleration time (DT) were 8.9 and 192.4 ms. In relation of diastolic function and degree of night BP reduction, LVM index was not correlated with degree of night BP reduction, However, E/E′ was mildly negative correlation with degree of night BP reduction. (r = −0.257, p = 0.004) DT was mildly positive correlation with degree of night BP reduction. (r = 0.236, p = 0.009) In addition, LAV index was strongly negative correlation with degree of night BP reduction. (r = −0.637, p < 0.001). Conclusions: In late third trimester of pregnancy, degree of nocturnal blood pressure in pregnancy might be associated with enlargement of the LAV.