MPS 08-03 Uric acid, all cause and cardiovascular mortality

Abstract

Objective: Serum uric acid (SUA) is reported to be associated with cardiovascular and all-cause mortality but previous studies have shown inconsistent results. The aim of this study was to investigate whether SUA is independently associated with cardiovascular and all-cause mortality in relatively healthy Korean adults. Design and Method: A total of 396,951 individuals from Kangbuk Samsung Health Care Center who participated in comprehensive health examination were enrolled between 2002 and 2012. 40,941 subjects were excluded for various reasons. All-cause and cardiovascular mortality data were collected. The total population was grouped according to baseline uric acid quartiles. Cox proportional hazards models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CIs), for all cause and cardiovascular mortality and the lowest SUA quartile group was the reference group. Results: A total of 357,032 subjects were eligible for the analysis and mean follow up duration were 5.67 ± 3.29 years. The lowest and highest quartiles of SUA were < 5.4 mg/dL, ≥ 7.0 mg/dL in men and < 3.6 mg/dL and ≥4.8 mg/dL in women. 2028 deaths (312 from cardiovascular disease and 1770 from other causes) occurred during follow-up. In the highest SUA group, adjusted hazard ratio for all-cause mortality were 1.10 [0.93, 1.30] in men and 0.89 [0.68, 1.16] in women; and for cardiovascular mortality were 1.22 [0.80, 1.86] in men and 0.80 [0.42, 1.53] in women after adjustment of age, sex, year of screening exam, smoking status, body mass index, alcohol intake, regular exercise, educational level, history of hypertension, diabetes and CVD. Conclusions: In this large relatively healthy population based observational study, SUA showed no significant association with all-cause and cardiovascular mortality.