MP91-05 DO ALCOHOL, SMOKING AND MALE AGE AFFECT SEMEN PARAMETERS AND IVF/ICSI OUTCOMES?

Abstract

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation1 Apr 2016MP91-05 DO ALCOHOL, SMOKING AND MALE AGE AFFECT SEMEN PARAMETERS AND IVF/ICSI OUTCOMES? Fahad AlMashat, Saad Abumelha, Chris Poullis, Tet Yap, Nagla Rushwan, Hossam Abdalla, Meen Yau Thum, and Suks Minhas Fahad AlMashatFahad AlMashat More articles by this author , Saad AbumelhaSaad Abumelha More articles by this author , Chris PoullisChris Poullis More articles by this author , Tet YapTet Yap More articles by this author , Nagla RushwanNagla Rushwan More articles by this author , Hossam AbdallaHossam Abdalla More articles by this author , Meen Yau ThumMeen Yau Thum More articles by this author , and Suks MinhasSuks Minhas More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2592AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To determine the effects of alcohol, smoking and male age on semen parameters and the outcomes from IVF/ICSI. METHODS Records of couples attending a single IVF Unit were retrospectively reviewed (2013 to 2014). The age, number of cigarettes smoked/day and number of units of alcohol consumed/week were recorded along with semen parameters performed on the day of IVF/ICSI. Couples with the female age over 37 years were excluded. Smoking was sub-categorized into (1-9, 10-20 and > 20) cigarettes/day, and alcohol consumption (1-4, 5-10, 11-20 and >20) units/week. A multivariate analysis of the effects of age, alcohol consumption and smoking on semen parameters and outcome from IVF/ICSI was performed. RESULTS 1257 couples attended for fertility assessment. Mean age was 36.4 (Range 23-76). Mean Female age was 34 (Range 20-37). 13% (n=162) of males were smokers (mean 9 cigs/day). 77% (n=964) of males had a history of alcohol consumption (mean 9.8 units/week). 35.8% (n=450) of couples underwent IVF treatment, 57% (n=717) underwent ICSI and 7.2% (n=90) had failure of embryo development. Increasing male age was associated with a reduction in semen volume, sperm count, motility and morphology (p< 0.05). Fertilization rate, pregnancy and live birth rate were unaffected (p=0.603, p=0.895 and p=0.088 respectively). Smoking in all groups showed a reduction in sperm count only. There were no differences in ICSI outcome between smokers and non-smokers. With IVF, smoking reduced pregnancy rates (p=0.049) but not fertilization or life birth rates (p=0.081 and p=0.219 respectively). Alcohol affected sperm motility and morphology (p < 0.0001) but not volume or count (p=0.544 and p=0.232 respectively). In IVF, pregnancy rate was reduced (p<0.048) but not fertilisation and live birth rates (p=0.847and p=0.063 respectively). In ICSI, fertilization rates were reduced (p<0.013) but not pregnancy and live births (p<0.132 and p<0.099 respectively). No correlation between the number of cigarettes or alcohol units and the outcome of IVF/ICSI was established. CONCLUSIONS Age, smoking and alcohol impair semen parameters. The number of cigarettes and amount of alcohol consumed did not correlate with IVF/ICSI outcome. Live birth rates from IVF/ICSI are not affected by these factors suggesting that these technologies improve fertility outcomes by optimising sperm selection. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1154-e1155 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Fahad AlMashat More articles by this author Saad Abumelha More articles by this author Chris Poullis More articles by this author Tet Yap More articles by this author Nagla Rushwan More articles by this author Hossam Abdalla More articles by this author Meen Yau Thum More articles by this author Suks Minhas More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...