MP91-10 THE EARLY AND LATE EFFECTS OF CANCER ON MALE FERTILITY

Abstract

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation1 Apr 2016MP91-10 THE EARLY AND LATE EFFECTS OF CANCER ON MALE FERTILITY Saad Abumelha, Chris Poullis, Fahad Al Mashat, Tet Yap, Elizabeth Williamson, David Ralph, and Suks Minhas Saad AbumelhaSaad Abumelha More articles by this author , Chris PoullisChris Poullis More articles by this author , Fahad Al MashatFahad Al Mashat More articles by this author , Tet YapTet Yap More articles by this author , Elizabeth WilliamsonElizabeth Williamson More articles by this author , David RalphDavid Ralph More articles by this author , and Suks MinhasSuks Minhas More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2597AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The effects of cancers on male fertility are under reported. The aim of this study was to analyze the impact of different cancer pathologies on spermatogenesis in men. METHODS A retrospective review of patients (2010-2014) diagnosed with cancer undergoing sperm cryopreservation prior to medical or surgical intervention was conducted. The semen volume, sperm concentration, overall motility and morphology were reported in accordance with WHO 2010 values. The main tumour groups analysed were testis, leukaemia, lymphoma, prostate, sarcoma and central nervous system (CNS). RESULTS A total of 1067 consecutive patients were included. The median age was 31 (IQR 25 - 39). Azoospermia was reported in 7/1067 (0.7 %) patients, severe oligozoospermia (=1 million (M) sperm/ml) 64/1067 (6.0%) of patients and oligozoospermia (<15M sperm/ml) in 325/1067 (30.5%). An additional cohort of 102 patients who had relapsed tumors post medical/surgical intervention had a rate of azoo/oligozoospermia of 48.02% (n=49). Median sperm concentration was significantly different between tumour groups (p<0.005 Kruskal Wallis), with testis tumours (pre-orchidectomy) having the lowest median concentrations (14 million/ml) and CNS tumours having, the highest (29 million/ml) despite having no significant difference in age between the two groups. CONCLUSIONS Sperm cryopreservation prior to treatment is mandatory and an important aspect of survivorship management and planning, with up to 0.7% of men potentially requiring surgical sperm retrieval for azoospermia. Up to 40% of men with cancer are subfertile increasing to 48% in those presenting after relapse. Further research is required to understand and target future fertility therapies in this cohort of relatively young men. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1157 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Saad Abumelha More articles by this author Chris Poullis More articles by this author Fahad Al Mashat More articles by this author Tet Yap More articles by this author Elizabeth Williamson More articles by this author David Ralph More articles by this author Suks Minhas More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...