MP90-18 SILODOSIN FOR MEDICAL EXPULSIVE THERAPY IN CHILDREN WITH DISTAL URETERAL STONE: A PROSPECTIVE RANDOMIZED, PLACEBO-CONTROLLED, SINGLE BLIND STUDY STUDY

Abstract

You have accessJournal of UrologyStone Disease: Medical & Dietary Therapy1 Apr 2017MP90-18 SILODOSIN FOR MEDICAL EXPULSIVE THERAPY IN CHILDREN WITH DISTAL URETERAL STONE: A PROSPECTIVE RANDOMIZED, PLACEBO-CONTROLLED, SINGLE BLIND STUDY STUDY Ahmed fahmy, hazem Rhasad, Amr Kamal, and Moustafa Elsawy Ahmed fahmyAhmed fahmy More articles by this author , hazem Rhasadhazem Rhasad More articles by this author , Amr KamalAmr Kamal More articles by this author , and Moustafa ElsawyMoustafa Elsawy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2837AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Silodosin, a selective a1-blocker,has been proposed for medical expulsive therapy (MET) instead of tamsulosin in adulthood urolithiasis with promising outcomes but studies comparing these substances for MET in children are lacking. The aim of this study was to verify the safety and efficacy of silodosin (8 mg) compared with tamsulosin (0.4 mg) and placebo as a MET for distal ureteral stones in children. METHODS A prospective randomized placebo-controlled study including 90 children diagnosed with unilateral, single, radio-opaque distal ureteral stones < 10 mm in size was conducted. Age ranged between 5.8 and 18 years old. Patients were randomized into three groups; silodosin group (n = 30) received 8 mg silodosin daily, tamsulosin group (n = 30) received 0.4 mg tamsulosin daily and placebo group (n = 30) were not given any of the above medications. Patients were offered a closely monitored trial for spontaneous stone passage in the 4-week period prior to definitive therapy. The stone clearance rate, time to stone clearance, number of pain episodes, need for analgesia and potential side effects of medications were observed. RESULTS The stone clearance rates for silodosin, tamsulosin and placebo groups were 78.5, 66.6 and 53.3 %, respectively. The time to stone clearance was significantly shorter in silodosin and tamsulosin groups than in placebo group (p = 0.006 and 0.035, respectively). Patients taking silodosin and tamsulosin had fewer pain attacks and lesser analgesic requirement than placebo group patients. CONCLUSIONS The current study showed the use of a-blockers for MET of lower ureteric stones in children to be effective, however, the use of silodosin was associated with higher stone clearance rates and shorter time to stone clearance as compared to tamsulosin. Both of these medications demonstrated a good safety and tolerability profile for MET in children with uncomplicated ureteral stones. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1217 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Ahmed fahmy More articles by this author hazem Rhasad More articles by this author Amr Kamal More articles by this author Moustafa Elsawy More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...