MP90-14 DISTINCT BIOLOGICAL FEATURES OF PROSTATE TUMORS IN THE CONTEXT OF RACE/ETHNICITY AND ERG STATUS

Abstract

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology IV1 Apr 2016MP90-14 DISTINCT BIOLOGICAL FEATURES OF PROSTATE TUMORS IN THE CONTEXT OF RACE/ETHNICITY AND ERG STATUS Jennifer Cullen, Denise Young, Yongmei Chen, Michael Degon, Wagner Baptist, James Farrell, Jason Sedarsky, Claire Huai-Ching Kuo, Jacob Kagan, Sudhir Srivastava, Inger Rosner, Gyorgy Petrovics, Albert Dobi, David McLeod, Shiv Srivastava, and Isabell Sesterhenn Jennifer CullenJennifer Cullen More articles by this author , Denise YoungDenise Young More articles by this author , Yongmei ChenYongmei Chen More articles by this author , Michael DegonMichael Degon More articles by this author , Wagner BaptistWagner Baptist More articles by this author , James FarrellJames Farrell More articles by this author , Jason SedarskyJason Sedarsky More articles by this author , Claire Huai-Ching KuoClaire Huai-Ching Kuo More articles by this author , Jacob KaganJacob Kagan More articles by this author , Sudhir SrivastavaSudhir Srivastava More articles by this author , Inger RosnerInger Rosner More articles by this author , Gyorgy PetrovicsGyorgy Petrovics More articles by this author , Albert DobiAlbert Dobi More articles by this author , David McLeodDavid McLeod More articles by this author , Shiv SrivastavaShiv Srivastava More articles by this author , and Isabell SesterhennIsabell Sesterhenn More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2558AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Oncogenic activation of the ERG in prostate cancer (CaP) results from tumor cell specific gene fusions (predominantly TMPRSS2-ERG) that encode truncated ERG oncoprotein. Despite the prevalence of ERG alterations in CaP, emerging reports have underscored remarkable differences in the frequency of ERG alterations among different racial/ethnic groups. In this study, ERG oncoprotein status is compared in a large cohort of African American (AA) and Caucasian American (CA) men within an equal-access military healthcare system and examined for its association with CaP progression. METHODS Representative sections of whole mounted prostatectomy specimens from AA (N=373) and CA (N=684) patients were evaluated for ERG oncoprotein status by previously established immuno-histochemistry assays that showed very high concordance between ERG oncoprotein expression and ERG genomic fusions. ERG positive or negative status of index prostate tumors was analyzed for associations with self reported race/ethnicity, BMI, tumor grade, stage, multi-focality, and biochemical recurrence (BCR) and distant metastasis. RESULTS Comparison of ERG frequencies in index tumors of AA and CA men confirmed the significantly lower rate of ERG alterations in this large cohort of AA CaP. Another striking finding was the significant association between negative ERG index tumor status with greater odds of BCR and metastasis over time for CA men, controlling for key clinical covariates. CONCLUSIONS Distinct biological behavior of ERG positive or negative tumors in the context of race was evident in this study. These data are consistent with some of the previous reports including ours. This large cohort study underscores that ERG negative index status in CA men is predictive of disease progression. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1150 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Jennifer Cullen More articles by this author Denise Young More articles by this author Yongmei Chen More articles by this author Michael Degon More articles by this author Wagner Baptist More articles by this author James Farrell More articles by this author Jason Sedarsky More articles by this author Claire Huai-Ching Kuo More articles by this author Jacob Kagan More articles by this author Sudhir Srivastava More articles by this author Inger Rosner More articles by this author Gyorgy Petrovics More articles by this author Albert Dobi More articles by this author David McLeod More articles by this author Shiv Srivastava More articles by this author Isabell Sesterhenn More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...