MP90-07 THE EFFECT OF POTASSIUM CITRATE ON THE HEALTH-RELATED QUALITY OF LIFE OF STONE FORMERS

Abstract

You have accessJournal of UrologyStone Disease: Medical & Dietary Therapy1 Apr 2017MP90-07 THE EFFECT OF POTASSIUM CITRATE ON THE HEALTH-RELATED QUALITY OF LIFE OF STONE FORMERS Eric Raffin, Kristina Penniston, Stephen Nakada, Jodi Antonelli, Davis Viprakasit, Timothy Averch, Sri Sivalingam, Roger Sur, Ben Chew, Vincent Bird, Lawrence Dagrosa, Rebecca Smith, and Vernon Pais Eric RaffinEric Raffin More articles by this author , Kristina PennistonKristina Penniston More articles by this author , Stephen NakadaStephen Nakada More articles by this author , Jodi AntonelliJodi Antonelli More articles by this author , Davis ViprakasitDavis Viprakasit More articles by this author , Timothy AverchTimothy Averch More articles by this author , Sri SivalingamSri Sivalingam More articles by this author , Roger SurRoger Sur More articles by this author , Ben ChewBen Chew More articles by this author , Vincent BirdVincent Bird More articles by this author , Lawrence DagrosaLawrence Dagrosa More articles by this author , Rebecca SmithRebecca Smith More articles by this author , and Vernon PaisVernon Pais More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2826AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Potassium citrate has an established role in medical management of stone disease but many patients have reported unwanted side effects, notably gastrointestinal (GI). It is not currently well understood how the benefits of potassium citrate affect patients' health-related quality of life (HRQOL). We sought to evaluate the effect of potassium citrate on patients' stone-related HRQOL. METHODS Utilizing the previously validated Wisconsin Stone-QOL questionnaire (WISQOL), a kidney stone-specific instrument, we analyzed cross-sectional data from patients both new to and already established in stone prevention who were enrolled at sites participating in the North American Stone Quality of Life Consortium. We compared HRQOL in the WISQOL domains of social impact, emotional impact, disease impact, and vitality between patients prescribed potassium citrate and those not. In addition to student's t-test, multivariate linear regression controlling for age, gender, BMI, and number of stone events was performed to determine the strength of any differences found. Additionally, univariate and multivariate logistic regression were used to assess the likelihood of complaints of nausea and stomach upset or cramps between those prescribed and not prescribed potassium citrate. RESULTS 1511 stone formers were included (787 male, 724 female), of whom 258 were on potassium citrate at study enrollment. Patients prescribed potassium citrate scored significantly higher (better HRQOL) in each of the domains. With multivariate analysis, these differences maintained their significance (mean domain scores were higher by 2.5, 2.8, 2.8, 1.3 points, respectively, all p<0.0001). In item-level analysis, patients prescribed potassium citrate were less likely than those not prescribed it to report any nausea, stomach upset or cramps (43% vs 55%, p<0.001). Multivariate logistic regression showed a 40% lower likelihood of having GI complaints among patients prescribed potassium citrate, p=0.001, when controlling for the aforementioned factors. CONCLUSIONS Among chronic stone forming patients, the use of potassium citrate is associated with higher HRQOL across all domains of the WISQOL. Those prescribed potassium citrate appear less likely to endorse GI complaints compared to those not. These findings may be useful when encouraging patients to consider initiating potassium citrate therapy. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1212-e1213 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Eric Raffin More articles by this author Kristina Penniston More articles by this author Stephen Nakada More articles by this author Jodi Antonelli More articles by this author Davis Viprakasit More articles by this author Timothy Averch More articles by this author Sri Sivalingam More articles by this author Roger Sur More articles by this author Ben Chew More articles by this author Vincent Bird More articles by this author Lawrence Dagrosa More articles by this author Rebecca Smith More articles by this author Vernon Pais More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...