MP89-05 THE ASSESSMENT OF HORMONE REPLACEMENT THERAPY SUCCESS DUE TO HYPOGONADOTROPHIC HYPOGONADISM

Abstract

You have accessJournal of UrologyInfertility: Therapy I1 Apr 2017MP89-05 THE ASSESSMENT OF HORMONE REPLACEMENT THERAPY SUCCESS DUE TO HYPOGONADOTROPHIC HYPOGONADISM Emre Salabas, Ebubekir Buyuk, Caner Bese, Mazhar Ortac, and Ates Kadioglu Emre SalabasEmre Salabas More articles by this author , Ebubekir BuyukEbubekir Buyuk More articles by this author , Caner BeseCaner Bese More articles by this author , Mazhar OrtacMazhar Ortac More articles by this author , and Ates KadiogluAtes Kadioglu More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2803AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Hypogonadatrophic hypogonadism is a rare disease in which medical treatment has high success rates for infertility. The aim of this study was to analyze the efficacy of hormone replacement therapy on the infertile patients with hypogonadotrophic hypogonadism (HH) diagnosis. METHODS A total of 250 patients had been diagnosed as HH between years 2002-2016 underwent Cella Pituitary MR imaging to exclude intracranial pathology, genetic and biochemical(hormone) analysis. Patients ,who had been diagnosed as HH with low testosterone and FSH levels but without surgical requirement, were administered LH analogues (Recombinant choriogonadotropin) and Recombinant FSH as hormone replacement therapy. Patient followed up was carried out with quarterly semen analysis and hormonal profiles. Detection of sperm in ejaculate and achievement of pregnancy spontaneously or with assisted reproductive tecniques were the predetermined primary and secondary endpoints. RESULTS The patients with regular follow-ups (135) had been selected out of the HH database with 250 patients and retrospectively investigated. During the treatment period(8-24 months), 94 (70%) patients had sperm appearance in their ejaculate. Out of the 72 married males with sperm appearing on their ejaculate, 40 patients (55%) obtained pregnancy spontaneously; 7 patients (%10) via assisted reproductive techniques. Forty one patients (%30) who had no sperm in their ejaculate yet are under routine control with hormonal treatment. CONCLUSIONS The medical approach of males ,with hypogonadotropic hypogonadism and azoospermia, is a successful treatment modality both in terms of sperm presence in ejaculate and pregnancy rates. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1203-e1204 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Emre Salabas More articles by this author Ebubekir Buyuk More articles by this author Caner Bese More articles by this author Mazhar Ortac More articles by this author Ates Kadioglu More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...