MP88-10 IMPACT OF RADIOTHERAPY ON URINARY CONTINENCE AND QOL AFTER RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Male Incontinence: Therapy1 Apr 2015MP88-10 IMPACT OF RADIOTHERAPY ON URINARY CONTINENCE AND QOL AFTER RADICAL PROSTATECTOMY Joanne Nyarangi-Dix, Johannes Steimer, Hildegard Jakobi, Boris Hadaschik, and Markus Hohenfellner Joanne Nyarangi-DixJoanne Nyarangi-Dix More articles by this author , Johannes SteimerJohannes Steimer More articles by this author , Hildegard JakobiHildegard Jakobi More articles by this author , Boris HadaschikBoris Hadaschik More articles by this author , and Markus HohenfellnerMarkus Hohenfellner More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1843AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To investigate the influence of time of initiation of and indication for radiotherapy (RT) on urinary continence and QOL-outcomes after radical prostatectomy. METHODS The Heidelberg prospective tumor-data-base was searched for men receiving RT after radical prostatectomy (RP). These were assigned in adjuvant (ART), early salvage (ESRT) and salvage radiotherapy (SRT) groups depending on time, indication and pre-RT-PSA (¡Ü/>0.5ng/ml). We evaluated patient-reported urinary continence and QOL-outcomes. RESULTS Complete data was available for 251 men. Mean follow-up was 5.1years (range: 0.4-22.4yrs.). 84, 96 and 71 men received ART, ESRT, and SRT respectively. Mean time to RT was 0.3(¡À0.4), 1.8(¡À2.5) and 3.3(¡À3.6) years. respectively. Mean age at RP and RT was 63.9(¡À6.1) and 65.7(¡À6.2) years respectively; differences in age at RP (p=0.54) and RT (p=0.47) between groups were not significant. Mean-RT-dose was similar (p=0.70). Overall continence rate was 61.4%. No significant difference was found in continence distribution between groups prior (p=0.56) to and after RT (p=0.38). We also found no significant differences in frequency (p=0.58) or amount of urine loss (p=0.88), impact on QOL (p=0.13) and ICIQ-SF scores (p=0.69) between groups. Even though there was no significant difference in post-RT-continence in the direct comparison between study groups (p=0.89), a significant longitudinal worsening of continence was noted (p< 0.001). CONCLUSIONS This is the first analysis evaluating the impact of time of initiation and indication for RT on urinary continence. We demonstrate that RT adversely affects postoperative continence. This negative effect is irrespective of time of initiation of RT or indication for RT. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e1096 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Joanne Nyarangi-Dix More articles by this author Johannes Steimer More articles by this author Hildegard Jakobi More articles by this author Boris Hadaschik More articles by this author Markus Hohenfellner More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...