MP85-03 PROSPECTIVE MEASUREMENT OF PLASMA NEUTROPHIL GELATINASE-ASSOCIATED LIPOPROTEIN IN LIVING KIDNEY DONOR NEPHRECTOMY

Abstract

You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation & Vascular Surgery II1 Apr 2015MP85-03 PROSPECTIVE MEASUREMENT OF PLASMA NEUTROPHIL GELATINASE-ASSOCIATED LIPOPROTEIN IN LIVING KIDNEY DONOR NEPHRECTOMY Young Eun Yoon, Kyung Hwa Choi, Kwang Hyun Kim, Seung Choul Yang, and Woong Kyu Han Young Eun YoonYoung Eun Yoon More articles by this author , Kyung Hwa ChoiKyung Hwa Choi More articles by this author , Kwang Hyun KimKwang Hyun Kim More articles by this author , Seung Choul YangSeung Choul Yang More articles by this author , and Woong Kyu HanWoong Kyu Han More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1857AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Neutrophil gelatinase-associated lipocalin (NGAL) is a marker for acute kidney injury. This study was conducted to determine the clinical implications of perioperative plasma NGAL in relation to renal function after living donor nephrectomy. METHODS Between July 2013 and May 2014, 112 donors in our hospital underwent live donor nephrectomy. Donor plasma NGAL was measured perioperatively until 6 month, and changes in perioperative plasma NGAL was investigated. The relationships between perioperative plasma NGAL and recovery of renal function was analyzed. Renal function was estimated with the Modification of Diet in Renal Disease (MDRD) formula. RESULTS Mean preoperative NGAL was 62.1±29.5 ng/mL. Plasma NGAL was most elevated at 1 week postoperatively (218±95.5 ng/mL) and stabilized after 1 month (122.9±45.3 ng/mL, figure 1). Preoperative plasma NGAL was not correlated with donor age (r=0.061, p=0.524) and preoperative eGFR (r=-0.164, p=0.084), but correlated with 6-month eGFR (r=-0.458, p<0.001). During the observation period, plasma NGAL at 1 week was most correlated with 6-month eGFR (r=-0.554, p<0.001). An ROC curve analysis showed that age, preoperative eGFR, and 1-week postoperative plasma NGAL were highly predictive of developing of chronic kidney disease (CKD; eGFR<60 ml/min/1.73m2) at 6 month (AUC=0.91; p<0.001). One-week postoperative plasma NGAL was associated with CKD at 6 month (odds ratio: 1.13 for each 10 ng/ml increase; p=0.013). CONCLUSIONS Plasma NGAL becomes elevated after kidney donation and can provide information about acute kidney injury during the compensatory hyperfiltration period. Donors with a perioperatively increased plasma NGAL require close observation because there may be a greater possibility of CKD developing after donation. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e1067-e1068 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Young Eun Yoon More articles by this author Kyung Hwa Choi More articles by this author Kwang Hyun Kim More articles by this author Seung Choul Yang More articles by this author Woong Kyu Han More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...